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SSHD molecules

SSHD-KLO/GH1/IL7





SSHD-KLO/GH1/IL7

When genes KL, GH1 and IL-7 are targeted with the help of appropriate DNA molecules. The optimal function of these genes keeps the cell mediated and humoral immune systems as active and stable as possible as people age to reduce the likelihood of disease development. SSHD-KL/GH1/IL7 DNAs help everyone to live a longer disease-free life and slow down the aging process.

What do genes KL, GH1 and IL-7 do?

Since its discovery, scientists have shown that the KL gene, which synthesises the hormone Klotho, plays a very important role in slowing down the ageing process [1]. Scientists have shown in an animal model that reduced activity of KL results in acceleration of the aging of many organs, and in particular, skin deterioration and wrinkling [2]. These features are completely reversed by up-regulation of KL [3].

More recently, Dr. Witkowski and co-workers showed that reduced KL activity is associated with impaired immunity and increased susceptibility to development of auto-immunity [4]. These scientists demonstrated that KL plays an important role in stabilising CD4+ helper T lymphocytes, cells that promote and control the activity of the immune system.

IL-7, on the other hand, is a natural cytokine that has the ability to stimulate the production of new immuno-competent cells in the bone marrow [5]. As well as helping to boost the production of immune cells that kill virus infected cells and cells that make antibodies to neutralise toxins and infectious agents, it helps to boost the production of new immune cells in those that suffer generalised immune deficiency.

Part of the aging process involves muscle loss. GH1 helps to reduce muscle loss and build up muscle by stimulating both the differentiation and proliferation of muscle precursor cells called 5 myoblasts. These are the cells that form new muscle. It also enhances new muscle growth by increasing amino acid uptake in newly forming muscle cells as well as other tissues [6].

References

  1. Rosenblatt & Kuro-O. Klotho, an aging suppressor gene. Horm. Res., 2007: 67;191.
  2. Kuro-o M et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature. 1997:390;45.
  3. Kurosu H et al. Suppression of aging in mice by the hormone Klotho. Science. 2005:309; 1829.
  4. Witkowski et al., Klotho- a common link in physiological and rheumatoid arthritis-related aging of human CD4+ lymphocytes. J. Immunol., 2007: 178; 771.
  5. http://www.cytheris.com/Science/interleukin7.php.
  6. http://en.wikipedia.org/wiki/Growth_hormone.

Want to know more?

For more information about this SSHD molecule, contact your healthcare practitioner or arrange an appointment using our clinic.

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