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SSHD molecules

SSHD-HSF





SSHD-HSF

The HSF1 gene repairs damaged proteins that cause ill-health. The SSHD-HSF molecule promotes the activity of HSF1 gene.

Activity of the HSF1 gene should be promoted in most people on a permanent basis, particularly those suffering from chronic inflammatory disorders. This recommendation is not for use in cancer patients because such promotion of HSF1 gene is likely to protect cancer cells from the cytotoxic effects of radiotherapy and chemotherapy.

What does the HSF1 gene do?

There are almost a million proteins that are required to organise and carry out all the physiological and psychological functions that are needed to maintain optimum health throughout life.

The most effective function of a protein depends very much on its tertiary structure, that is, the precise way in which it is folded. For a protein to work effectively, it must have the correct fit with its receptor, rather like a lock and key fitting system. Unfortunately, the correct tertiary structure of many proteins is often difficult to maintain because their structure is altered by exposure to many factors such as increased temperature, toxins, radiation from all sources including sun exposure, electromagnetic radiation, infectious agents and more. Because the tertiary structure of proteins is dependent on temperature, the heat generated by conditions associated with chronic inflammation can also affect the structure and hence the optimum health promoting properties of many proteins.

Fortunately, over millions of years, the body has developed a series of molecules called heat shock proteins. Their job is to seek out dysfunctional proteins that have been disfigured by exposure to cellular stresses and repair/refold them back to their correct tertiary structure so that they once again become fully functional. It follows therefore that promotion of all these protein repair systems would result in better all-round health, particularly in conditions associated with chronic inflammation as well as extending a healthy life.

There are many members of the heat shock protein repair family, however, the master regulator of all of them is HSF1. That is why the SSHD-HSF molecule is prepared to target the HSF1 gene. The SSHD-HSF molecule has been designed to target the HSF1 gene so that it can co-ordinate the whole of the body's protein repair systems. In this way, disfigured dysfunctional proteins can be refolded and repaired so that they can function at full capacity. Maximum health is enjoyed when all the body's cellular components and proteins are fully functional.

In 2011, Dr. Anckar and colleague published a highly informative article describing the important health promoting properties of HSF1 [1].

References

  1. Anckar and Sistonen. Regulation of HSF1 function in the heat stress response: Implications in aging and disease. Ann. Rev. Biochem. 2011: 80, 1089.

Want to know more?

For more information about this SSHD molecule, contact your healthcare practitioner or arrange an appointment using our clinic.

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