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SSHD molecules

SSHD-CTR





SSHD-CTR

The CTR gene is responsible to synthesise a gene product to strengthen bone to avoid bone fractures, particularly in post-menopausal women. Optimisation of CTR gene function increases calcitonin receptor protein and plays an important role in bone formation. The SSHD-CTR molecule targets CTR gene.

What does CTR gene do?

The gene that encodes the calcitonin receptor (CTR) was completely characterised by Gorn and colleagues [1]. It is located on human chromosome 7 and encodes a cell membrane component that acts as a receptor for the hormone calcitonin and plays an important role in bone formation. Bone is continually being broken down by osteoclasts and rebuilt by osteoblasts. The interaction between calcitonin and CTR plays an important role in the process of the rebuilding and strengthening of bone.

The increased activity of CTR gene helps the body produce more of the calcitonin receptor protein. Bone is continually been broken down and rebuilt. The calcitonin receptor supports the activity of cells that build up bone resulting in stronger bones and reduced susceptibility to bone fracture, especially in post-menopausal women.

Dr Taboulet and colleagues [2] discovered that post-menopausal women are less likely to fracture their bones through a form of natural super-health involving the CTR gene.

References

  1. Gorn et al., Expression of two human skeletal calcitonin receptor isoforms cloned from a giant cell tumor of bone. J. Clin. Invest., 95: 2680, 1995.
  2. Taboulet et al., Calcitonin receptor polymorphism is associated with a decreased fracture risk in post-menopausal women. Hum. Molec. Genet., 7: 2129, 1998.

Want to know more?

For more information about this SSHD molecule, contact your healthcare practitioner or arrange an appointment using our clinic.

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