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Homeovitality® products

Homeovitality Migraban

May assist with the treatment of migraines

Homeovitality® Migraban

The Homeovitality remedy Migraban has been developed to target the KCNK18 and MTHFR genes because migraine has been shown to be associated with low KCNK18 activity and high blood levels of homocysteine.

What do the genes KCNK18 and MTHFR do?

The KCNK18 gene encodes a protein called TRESK, a TWIK-related spinal cord potassium channel that is involved in manifestation of pain.

Migraine and severe headaches are two of the most common debilitating disorders. After many years of investigation, it has now been recognised that reduced activity of TRESK plays a major role in increased susceptibility to the onset of migraine and severe headaches. This finding was the result of a large international investigation, see Ref. 1 and within, results of which was summarised in an article by the Migraine Trust [2].

These important studies have identified that reduced activity of the gene KCNK18, which encodes the pain controlling protein TRESK, which, as indicated above, plays a major role in development of migraine and severe headache. The HoV-KC18 remedy has been developed to target the KCNK18 gene.

In recent years, another important contributory factor has been recognised that increases susceptibility to development of migraine, and that is, a high level of the toxic amino acid homocysteine in the blood, see within Ref. 3.

The MTHFR gene encodes an enzyme called methylenetetrahydrofolate reductase, an enzyme involved in homocysteine degradation. The MTHFR gene product plays an important role in the conversion of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. This conversion reaction is required for the multistep process that converts the amino acid homocysteine back to another amino acid, methionine.

Decreased activity of MTHFR leads to inefficient conversion of homocysteine to methionine leading to a build up of homocysteine in the blood. High levels of homocysteine in the blood is not only associated with increased susceptibility to development of migraine but many other serious disorders such as heart disease, stroke, hearing loss and blood vessel deterioration, [see Ref. 4].


  1. http://www.sciencedaily.com/releases/2010/09/100927105351.htm?utm_source=rss&utm_medium=rss&utm_campaign=gene-linked-to-common-form-of-migraine-discovered
  2. http://www.migrainetrust.org/research-article-a-new-gene-for-migraine-2011-13152
  3. http://www.rejuvenation-science.com/n_homocysteine_headache.html
  4. El-Sammak et al.,Elevated plasma homocysteine is positively associated with age independent of C677T mutation of the methylenetetrahydrofolate reductase gene in selected Egyptian subjects. Int. J. Med. Sci. 2004: 1, 181.

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Additional Information




Acidum Nucleicum KC18/MTR UHD at 10-12, Stabiliser (Sodium Phosphate buffer) - 0.014mg/mL, Ethanol (25%) in purified water

Volume (of 1 bottle)

Each bottle contains 50mL of liquid which lasts 1½ months (if used twice a day)

Directions for use

Shake before use. Twice daily, add 8 drops to a little clean water. On a clean palate, rinse round mouth and swallow. More than one product can be taken in the same glass.

Do not use if seal is broken. Keep product in original container.


Keep away from strong odours. Store at room temperature, out of direct sunlight, excessive heat and away from children. Keep product in original container.


It is recommended that you inform your medical doctor/GP that you are taking Homeovitality products. Homeovitality products should not be used as a substitute for treatments prescribed by your physician (read the full disclaimer). A practitioner's prescription is not required to use Homeovitality products.

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